Mass Effect 2 run on insanity mode, Vanguard. One of the hardest missions in the game, it becomes available after you recruited all companions from the dossiers given to you by the Illusive Man. This is where you meet the Collectors face to face for the first time and it’s where you need to start playing aggressively as a vanguard in order to succeed.
Suggested companions: Miranda, Thane, Mordin. Miranda and Thane to get through the biotic barriers and armour with Warp. Miranda also gives a health and weapon damage buff to your party. Mordin with his Incinerate to help get through the armour of the Husks and the Scions.
I am using the Geth Plasma Shotgun as primary weapon and fall back on the Shuriken Machine Pistol when out of ammo. Using Reave as bonus power to help chew biotic barriers and armor, as well as healing myself when in danger.